Rochester Reporter

Eric J. Wagner, a professor of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry, has been honored as a fellow by the American Association for the Advancement of Science (AAAS). The AAAS is known as the world’s largest general scientific society and the publisher of the journal Science. Wagner's fellowship recognizes his contributions to molecular biology and biochemistry, specifically his research on RNA regulation in human cells and its implications for cancer and developmental disorders.

Wagner is one of 471 individuals chosen for the esteemed 2024 Fellow class, celebrated for their scientifically and socially significant career achievements. "Eric is a card-carrying RNA biologist and powerhouse of technological developments whose work is increasing our understanding of the causes of neuroblastoma and other devastating brain disorders in children,” said Lynne E. Maquat, PhD, director of the University of Rochester Center for RNA Biology.

Wagner's academic journey began with an undergraduate degree at the University of Rochester, followed by a PhD from Duke University and postdoctoral research at the University of North Carolina. Before returning to Rochester in 2021, Wagner led research labs at the University of Texas-Houston and University of Texas Medical Branch-Galveston. His work on the Integrator complex, which plays a pivotal role in gene expression management, has gained significant attention since its publication in 2014, highlighting its relevance to cancer and neurological development.

His research suggests that changes in the Integrator affect both cancer cell growth and brain development, offering potential new approaches for treating neuroblastoma and rare brain conditions such as BRAT-associated disorders. “In addition to being a leader in the ever-expanding field of RNA biology, Eric is also a wonderful mentor to many young scientists training in biochemistry, molecular and cellular biology, and cancer,” stated Steve Dewhurst, PhD, University of Rochester Vice President for Research.

Alongside his current research, Wagner continues exploring the impact of RNA length on cancer cell proliferation, a topic that holds promise for future cancer diagnostics. Receiving this fellowship is particularly meaningful for Wagner, symbolizing a significant milestone in his career that started at the same university where he now serves as a faculty member.